Endocrine Abstracts

Objectives: The extent and mechanisms of the diurnal variation in insulin sensitivity are poorly described. This study set out to assess the relative contributions of diurnal rhythm and length of fast to insulin sensitivity in normal healthy human subjects.Methods: Nine healthy women (age 25.3±1.2 years, BMI 22.4±0.8 Kg/m2) ate a standardised meal before each of the four fasts, two ten-hour fasts ending at 0900 and 1700 and two thirteen-hou...